In Brown and Lostroh (submitted), we present models for inferring gene activity dynamics from reporter protein time series data.  The method is implemented in the following Excel spreadsheets.  The first one is general, valid for any system in which the reporter protein is detectable immediately upon synthesis.  The second one is specific for GFP, incoporating a transitional period before the protein is fluorescent.  For details on the models and assumptions, please see the paper.  Each spreadsheet contains brief instructions in comment boxes.  Please feel free to download and use these spreadsheets, citing the paper by Brown and Lostroh (submitted).

Spreadsheet for general model.

Spreadsheet for GFP model.

If you have questions, please contact David Brown at:  dbrownATcoloradocollegeDOTedu